Mattsson-Carlgren N, Janelidze S, Palmqvist S, Cullen N, Svenningsson AL, Strandberg O, Mengel D, Walsh DM, Stomrud E, Dage JL, Hansson O. Brain. 2020 Dec 5;143(11):3234-3241 Abstract Plasma levels of tau phosphorylated at threonine-217 (p-tau217) is a candidate tool to monitor Alzheimer’s disease. We studied 150 cognitively unimpaired participants and 100 patients with mild cognitive […]
Monthly Archives: January 2021
Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer’s disease.
Pereira JB, Janelidze S, Ossenkoppele R, Kvartsberg H, Brinkmalm A, Mattsson-Carlgren N, Stomrud E, Smith R, Zetterberg H, Blennow K, Hansson O. Brain. 2020 Dec 5:awaa395. doi: 10.1093/brain/awaa395. Online ahead of print. Abstract It is currently unclear how amyloid-β and tau deposition are linked to changes in synaptic function and axonal structure over the course […]
The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects.
Smith R, Strandberg O, Mattsson-Carlgren N, Leuzy A, Palmqvist S, Pontecorvo MJ, Devous MD, Ossenkoppele R, Hansson O. Brain. 2020 Dec 1;143(12):3805-3815 Abstract The development of tau-PET allows paired helical filament tau pathology to be visualized in vivo. Increased knowledge about conditions affecting the rate of tau accumulation could guide the development of therapies halting […]
Derivation and utility of an Aβ-PET pathology accumulation index to estimate Aβ load.
Leuzy A, Lilja J, Buckley CJ, Ossenkoppele R, Palmqvist S, Battle M, Farrar G, Thal DR, Janelidze S, Stomrud E, Strandberg O, Smith R, Hansson O. Neurology. 2020 Nov 24;95(21):e2834-e2844 Abstract Objective: To evaluate a novel β-amyloid (Aβ)-PET-based quantitative measure (Aβ accumulation index [Aβ index]), including the assessment of its ability to discriminate between participants based […]
Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease
Janelidze S, Berron D, Smith R, Strandberg O, Proctor NK, Dage JL, Stomrud E, Palmqvist S, Mattsson-Carlgren N, Hansson O. JAMA Neurol. 2020 Nov 9:e204201. Abstract Importance: There is an urgent need for inexpensive and minimally invasive blood biomarkers for Alzheimer disease (AD) that could be used to detect early disease changes. Objective: To assess how early […]