🔗https://www.nature.com/articles/s41380-026-03838-3.pdf 🤝 A great collaboration between BioFINDER group and the University of Gothenburg, led by Juan Lantero-Rodriguez @MontoliuGaya and @gesalbla

Thanks to all participants and coauthors @SebastianPalmqv @A_OrdunaDolado @NiklasMattsson4 @EStomrud

This study was led by María Rivera Sánchez. A huge thanks to all co-authors: @SEMastenbroek, @NiklasMattsson4, @DaniellevWe, @EStomrud, @SebastianPalmqv, @RikOssenkoppele

This supports the potential of blood-based biological staging as scalable alternative to PET imaging for AD characterization. This approach may improve participant stratification for clinical trials and facilitate broader implementation of biological staging in clinical practice.

A huge thank you to all co-authors and collaborators for their incredible work on this project: @KantaHorie, @SuzanneESchind1, @A_OrdunaDolado, @tlsmit1, @BrianGordon81, @NiklasMattsson4, @SebastianPalmqv, @_JakeVogel_ @RandallBateman3, @RikOssenkoppele, and all not on X.

Using large-scale proteomics across multiple cohorts, we found that APOE ε4 and APOE ε2 have largely distinct protein signatures. Many changes appeared even before detectable Aβ pathology, suggesting that APOE-related molecular alterations may begin long before dementia develops.

A big thanks to all authors and collaborators!
@LuLina000147323, @ines_hristovska, @cumplido_irene, @anlijuncn, @RikOssenkoppele, @SebastianPalmqv, @_JakeVogel_, @EStomrud, @NiklasMattsson4

Big thanks to all authors and collaborators! @LECollij @gesalbla @KantaHorie @tobeybetthauser @ErikRubenSmith @SebastianPalmqv @SuzanneESchind1 @RikOssenkoppele @NiklasMattsson4 @RandallBateman3

This study was led by Beata Borgström Bolmsjö. A big thanks to all collaborators and co-authors: @DaniellevWe @SuzanneESchind1 @LECollij @ErikRubenSmith @NiklasMattsson4 @EStomrud @SebastianPalmqv and all not on X.

The study was led by @SEMastenbroek, a huge thank you to all co-authors: @LECollij, @teanijarv, @jorittmo, @YoungAlexL, @ErikRubenSmith, @NicolaSpotorno, @SebastianPalmqv, @NiklasMattsson4, @_JakeVogel_, @FBarkhof, @RikOssenkoppele and all not on X.

This study was led by @NiklasMattsson4, huge thanks to all co-authors: @SebastianPalmqv, @KantaHorie, @gesalbla, @tlsmit1, @LECollij, @RikOssenkoppele, @SuzanneESchind1, @EStomrud, @RandallBateman3, and all not on X.

This work was led by @ChaggarPavan, @_JakeVogel_, Niklas Mattsson-Carlgren, Oskar Hansson, @AlainGoriely.  Huge thanks to all coauthors: Travis Thompson, Roxana Aldea, Olof Strandberg, Erik Stomrud, Sebastian Palmqvist, @RikOssenkoppele, @SaadJbabdi, Stefano Magon, Gregory Klein!

We’d love to hear your thoughts and feedback!

Main takeaway:
CSF Ab42/Ab40 and plasma p-tau217 showed distinct contributions when predicting Aβ-PET, improving our understanding of disease progression and guiding how biomarkers can be applied in clinical and research settings.

Twitter feed image.

The study was led by @NiklasMattsson4, @karlssonlinda1, and Weizhong Tang. Thank you to all co-authors: Kaj Blennow, Henrik Zetterberg, @RandallBateman3, @SuzanneESchind1, Nicolas Barthelemy, @SebastianPalmqv, @EStomrud, Shorena Janelidze, and @OskarHansson9.

💡 Takeaway:
• NfL is robust but not sufficient alone in low-prevalence settings.
• Diagnostic and prognostic frameworks should move toward standardized multimodal models integrating fluid #biomarkers with established predictors.
#ALS #MND

Twitter feed image.

A huge thanks to all authors! @NiklasMattsson4

A huge thanks to all authors: @LECollij, @NiklasMattsson4, Shorena Janelidze, @RikOssenkoppele, and @OskarHansson9

The study was led by Atul Kumar. Thank you to all co-authors: @DivyaBali06, @EStomrud, @SebastianPalmqv, @_JakeVogel_, @OskarHansson9, @NiklasMattsson4, and those not on X.

🎯The use of plasma p-tau217 will reduce resource demands and burdensome procedures accelerating the development and implementation of early AD therapeutics.