Using large-scale proteomics across multiple cohorts, we found that APOE ε4 and APOE ε2 have largely distinct protein signatures. Many changes appeared even before detectable Aβ pathology, suggesting that APOE-related molecular alterations may begin long before dementia develops.

A big thanks to all authors and collaborators!
@LuLina000147323, @ines_hristovska, @cumplido_irene, @anlijuncn, @RikOssenkoppele, @SebastianPalmqv, @_JakeVogel_, @EStomrud, @NiklasMattsson4

Big thanks to all authors and collaborators! @LECollij @gesalbla @KantaHorie @tobeybetthauser @ErikRubenSmith @SebastianPalmqv @SuzanneESchind1 @RikOssenkoppele @NiklasMattsson4 @RandallBateman3

This study was led by Beata Borgström Bolmsjö. A big thanks to all collaborators and co-authors: @DaniellevWe @SuzanneESchind1 @LECollij @ErikRubenSmith @NiklasMattsson4 @EStomrud @SebastianPalmqv and all not on X.

The study was led by @SEMastenbroek, a huge thank you to all co-authors: @LECollij, @teanijarv, @jorittmo, @YoungAlexL, @ErikRubenSmith, @NicolaSpotorno, @SebastianPalmqv, @NiklasMattsson4, @_JakeVogel_, @FBarkhof, @RikOssenkoppele and all not on X.

This study was led by @NiklasMattsson4, huge thanks to all co-authors: @SebastianPalmqv, @KantaHorie, @gesalbla, @tlsmit1, @LECollij, @RikOssenkoppele, @SuzanneESchind1, @EStomrud, @RandallBateman3, and all not on X.

This work was led by @ChaggarPavan, @_JakeVogel_, Niklas Mattsson-Carlgren, Oskar Hansson, @AlainGoriely.  Huge thanks to all coauthors: Travis Thompson, Roxana Aldea, Olof Strandberg, Erik Stomrud, Sebastian Palmqvist, @RikOssenkoppele, @SaadJbabdi, Stefano Magon, Gregory Klein!

We’d love to hear your thoughts and feedback!

Main takeaway:
CSF Ab42/Ab40 and plasma p-tau217 showed distinct contributions when predicting Aβ-PET, improving our understanding of disease progression and guiding how biomarkers can be applied in clinical and research settings.

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The study was led by @NiklasMattsson4, @karlssonlinda1, and Weizhong Tang. Thank you to all co-authors: Kaj Blennow, Henrik Zetterberg, @RandallBateman3, @SuzanneESchind1, Nicolas Barthelemy, @SebastianPalmqv, @EStomrud, Shorena Janelidze, and @OskarHansson9.

💡 Takeaway:
• NfL is robust but not sufficient alone in low-prevalence settings.
• Diagnostic and prognostic frameworks should move toward standardized multimodal models integrating fluid #biomarkers with established predictors.
#ALS #MND

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A huge thanks to all authors! @NiklasMattsson4

A huge thanks to all authors: @LECollij, @NiklasMattsson4, Shorena Janelidze, @RikOssenkoppele, and @OskarHansson9

The study was led by Atul Kumar. Thank you to all co-authors: @DivyaBali06, @EStomrud, @SebastianPalmqv, @_JakeVogel_, @OskarHansson9, @NiklasMattsson4, and those not on X.

🎯The use of plasma p-tau217 will reduce resource demands and burdensome procedures accelerating the development and implementation of early AD therapeutics.

🙏Many thanks to all collaborators in this large study including 12 international cohorts: @DivyaBali06 @A_OrdunaDolado @JosephTherr @EStomrud @NiklasMattsson4 @EmmaCoomans @CharlotteTeuni1 @NesrineR95 @JuandoGispert @vincentDore2 @AzadehFeizpour

@DAlcoleaR @sylv_villeneuve @pedrorosaneto @SuzanneESchind1 @RikOssenkoppele @OskarHansson9 with data from @amsterdamumc @BarcelonaBeta @MayoClinicNeuro @mcgillu @prevent_ad @WashUMedADRC @WisconsinADRC… and those not in X.

The study was led by PhD students Pontus Tideman and @karlssonlinda1. Thank you also to all co-authors: @ErikRubenSmith @NiklasMattsson4 @EStomrud @SebastianPalmqv @OskarHansson9 and those not on X.

7/🧵 These results suggest that hemispheric difference in Aβ deposition, rather than reduction in connectivity, is associated with asymmetric tau accumulation, highlighting regional vulnerability as a crucial factor in determining the distribution of AD pathology.

Big thanks to all co-authors and collaborators: @RikOssenkoppele @ErikRubenSmith @LECollij @aitchbi @jorittmo @karlssonlinda1 @DaniellevWe @JakeVogel @EStomrud @SebastianPalmqv @NiklasMattsson4 @NicolaSpotorno @OskarHansson9 + those not on X

4⃣In summary, we have developed a biomarker-based staging model using plasma tau biomarkers and validated in TRIAD. We believe these findings will enhance the application of blood tau biomarkers, improving patient management in both clinical trials and routine clinical practice.

Thanks to all coauthors: @JosephTherr , @NicholasAshton, @andrealessa, @NiklasMattsson4, @SebastianPalmqv, @EStomrud, @pedrorosaneto, and @OskarHansson9
And those not on X.