Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson’s disease.

30 June, 2021

Abstract This study seeks a better understanding of possible pathophysiological mechanisms associated with cognitive impairment and dementia in Parkinson’s disease using structural and functional MRI. We investigated resting-state functional connectivity of important subdivisions of the caudate nucleus, putamen and thalamus, and also how the morphology of these structures are impacted in the disorder. We found

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Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures

24 June, 2021

Abstract A combination of plasma phospho-tau (P-tau) and other accessible biomarkers might provide accurate prediction about the risk of developing Alzheimer’s disease (AD) dementia. We examined this in participants with subjective cognitive decline and mild cognitive impairment from the BioFINDER (n = 340) and Alzheimer’s Disease Neuroimaging Initiative (ADNI) (n = 543) studies. Plasma P-tau,

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Association of CSF Aβ38 Levels With Risk of Alzheimer Disease-Related Decline.

14 June, 2021

Neurology. 2021 Dec 22:10.1212/WNL.0000000000013228. doi: 10.1212/WNL.0000000000013228. PMID: 34937781

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Biomarker-Based Prediction of Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.

JAMA Neurol. 2021 Dec 20:e214654. doi: 10.1001/jamaneurol.2021.4654..PMID: 34928318 Free PMC article.

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Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques.

Neurology. 2021 Dec 14:10.1212/WNL.0000000000013211. doi: 10.1212/WNL.0000000000013211..PMID: 34906975

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The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.

ALFA study†, BioFINDER, ADNI.Alzheimers Dement. 2021 Dec 8. doi: 10.1002/alz.12487.

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Characterization of pre-analytical sample handling effects on a panel of Alzheimer’s disease-related blood-based biomarkers: Results from the Standardization of Alzheimer’s Blood Biomarkers (SABB) working group.

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Connecting Cohorts to Diminish Alzheimer’s Disease (CONCORD-AD): A Report of an International Research Collaboration Network.

CONCORD-AD investigators.J Alzheimers Dis. 2022;85(1):31-45. doi: 10.3233/JAD-210525.

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The global Alzheimer’s Association round robin study on plasma amyloid β methods.

Alzheimers Dement (Amst). 2021 Oct 14;13(1):e12242. doi: 10.1002/dad2.12242. eCollection 2021.

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Genetic effects on longitudinal cognitive decline during the early stages of Alzheimer’s disease.

Sci Rep. 2021 Oct 6;11(1):19853. doi: 10.1038/s41598-021-99310-z.

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Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease.

JAMA Neurol. 2021 Nov 1;78(11):1375-1382. doi: 10.1001/jamaneurol.2021.3180.

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Comparing the Clinical Utility and Diagnostic Performance of CSF P-Tau181, P-Tau217, and P-Tau231 Assays.

Neurology. 2021 Oct 26;97(17):e1681-e1694. doi: 10.1212/WNL.0000000000012727. Epub 2021 Sep 7.

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Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer’s disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators.Lancet Neurol. 2021 Sep;20(9):739-752. doi: 10.1016/S1474-4422(21)00214-3.

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Tau-related grey matter network breakdown across the Alzheimer’s disease continuum.

Alzheimers Res Ther. 2021 Aug 13;13(1):138. doi: 10.1186/s13195-021-00876-7.

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Inter-modality assessment of medial temporal lobe atrophy in a non-demented population: application of a visual rating scale template across radiologists with varying clinical experience.

Eur Radiol. 2022 Feb;32(2):1127-1134. doi: 10.1007/s00330-021-08177-1. Epub 2021 Jul 30.

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Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease.

Brain. 2021 Dec 16;144(11):3505-3516. doi: 10.1093/brain/awab223.

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Tau PET correlates with different Alzheimer’s disease-related features compared to CSF and plasma p-tau biomarkers.

EMBO Mol Med. 2021 Aug 9;13(8):e14398. doi: 10.15252/emmm.202114398. Epub 2021 Jul 13.

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Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging.

JAMA Neurol. 2021 Aug 1;78(8):961-971. doi: 10.1001/jamaneurol.2021.1858.

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Detecting amyloid positivity in early Alzheimer’s disease using combinations of plasma Aβ42/Aβ40 and p-tau.

Alzheimers Dement. 2021 Jun 20. doi: 10.1002/alz.12395.

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Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations.

Nat Commun. 2021 Jun 11;12(1):3555. doi: 10.1038/s41467-021-23746-0.

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A multicentre validation study of the diagnostic value of plasma neurofilament light.

Nat Commun. 2021 Jun 7;12(1):3400. doi: 10.1038/s41467-021-23620-z.

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Sex differences in off-target binding using tau positron emission tomography.

Neuroimage Clin. 2021;31:102708. doi: 10.1016/j.nicl.2021.102708. Epub 2021 May 29.

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Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects.

Brain. 2021 Oct 22;144(9):2826-2836. doi: 10.1093/brain/awab163.

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The BIN1 rs744373 Alzheimer’s disease risk SNP is associated with faster Aβ-associated tau accumulation and cognitive decline.

Alzheimer’s Disease Neuroimaging Initiative (ADNI)* and the Swedish BioFINDER study.Alzheimers Dement. 2021 Jun 1. doi: 10.1002/alz.12371. Online ahead of print.

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A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis.

Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2295-2305. doi: 10.1007/s00259-021-05401-4. Epub 2021 May 27.

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Health utility in preclinical and prodromal Alzheimer’s disease for establishing the value of new disease-modifying treatments-EQ-5D data from the Swedish BioFINDER study.

Alzheimers Dement. 2021 Nov;17(11):1832-1842. doi: 10.1002/alz.12355. Epub 2021 May 13.

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Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau.

EMBO Mol Med. 2021 Jun 7;13(6):e14022. doi: 10.15252/emmm.202114022. Epub 2021 May 5.PMID: 33949133 Free PMC article.

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Four distinct trajectories of tau deposition identified in Alzheimer’s disease.

Nat Med. 2021 May;27(5):871-881. doi: 10.1038/s41591-021-01309-6. Epub 2021 Apr 29.

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Cerebrospinal fluid N-224 tau helps discriminate Alzheimer’s disease from subjective cognitive decline and other dementias.

Alzheimers Res Ther. 2021 Feb 8;13(1):38. doi: 10.1186/s13195-020-00756-6.

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Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia.

Nat Med. 2020 Mar;26(3):379-386

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Accelerated inflammatory aging in Alzheimer’s disease and its relation to amyloid,
tau, and cognition.

Sci Rep. 2021
Jan 21;11(1):1965.

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The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer’s
disease.

Alzheimers Dement. 2021 Jan 25. Online ahead of print.

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Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer’s
disease.

Transl Psychiatry.
2021 Jan 26;11(1):76.

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Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for
synaptic biomarkers.

Acta Neuropathol Commun. 2021 Feb 1;9(1):19.

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Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future
conversion to Alzheimer dementia in patients with mild cognitive impairment.

Alzheimers Res Ther. 2021 Mar 27;13(1):68.

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A multisite analysis of the concordance between visual image interpretation and
quantitative analysis of [18F]flutemetamol amyloid PET images.

Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2183-2199

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Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer’s
disease.

J Neurol Neurosurg Psychiatry. 2021 Apr 13:jnnp-2020-325497.

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Biomarker testing in MCI patients-deciding who to test.

Alzheimers Res Ther. 2021 Jan 7;13(1):14.

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Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts.

Alzheimer’s Disease Neuroimaging Initiative (ADNI).Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2259-2271

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