A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases.

14 September, 2023

Nat Aging. 2023 Aug 31. doi: 10.1038/s43587-023-00471-5.

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Cognitive effects of Lewy body pathology in clinically unimpaired individuals.

Nat Med. 2023 Aug;29(8):1971-1978. doi: 10.1038/s41591-023-02450-0.

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Clinical effects of Lewy body pathology in cognitively impaired individuals.

Nat Med. 2023 Aug;29(8):1964-1970. doi: 10.1038/s41591-023-02449-7.

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CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease.

Nat Med. 2023 Aug;29(8):1954-1963. doi: 10.1038/s41591-023-02443-z.

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Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring.

Nat Med. 2022 Dec;28(12):2555-2562. doi: 10.1038/s41591-022-02074-w.

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Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline.

Nat Med. 2022 Nov;28(11):2381-2387. doi: 10.1038/s41591-022-02049-x.

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Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology.

11 September, 2023

Nat Aging. 2022 Dec;2(12):1138-1144. doi: 10.1038/s43587-022-00310-z.

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Associations of CSF PDGFRβ With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes.

Neurology. 2023 Jul 4;101(1):e30-e39. doi: 10.1212/WNL.0000000000207358.

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Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.

Alzheimer’s Disease Neuroimaging Initiative. JAMA Neurol. 2023 Jun 1;80(6):614-623. doi: 10.1001/jamaneurol.2023.1067.

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Higher plasma β-synuclein indicates early synaptic degeneration in Alzheimer’s disease.

Alzheimers Dement. 2023 Apr 27. doi: 10.1002/alz.13103

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Clinical Utility of Tau Positron Emission Tomography in the Diagnostic Workup of Patients With Cognitive Symptoms.

JAMA Neurol. 2023 Jul 1;80(7):749-756. doi: 10.1001/jamaneurol.2023.1323.

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Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders.

Aust N Z J Psychiatry. 2023 Jul 21:48674231187312. doi: 10.1177/00048674231187312.

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Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Nat Immunol. 2023 Sep;24(9):1540-1551. doi: 10.1038/s41590-023-01588-w.

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