Individualized, cross-validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms.
25 October, 2024
Alzheimers Dement. 2024 Oct 17. doi: 10.1002/alz.14305. Online ahead of print. PMID: 39417379
Read the article
Biological mechanisms of resilience to tau pathology in Alzheimer’s disease.
12 October, 2024
Alzheimers Res Ther. 2024 Oct 12;16(1):221. doi: 10.1186/s13195-024-01591-9. PMID: 39396028 Free PMC article.
Read the article
Fluid biomarkers in the context of amyloid-targeting disease-modifying treatments in Alzheimer’s disease.
11 October, 2024
Med. 2024 Oct 11;5(10):1206-1226. doi: 10.1016/j.medj.2024.08.004. Epub 2024 Sep 9. PMID: 39255800 Free article. Review.
Read the article
Considerations for widespread implementation of blood-based biomarkers of Alzheimer’s disease.
6 October, 2024
Alzheimers Dement. 2024 Oct 6. doi: 10.1002/alz.14150. Online ahead of print. PMID: 39369283
Read the article
Recommendations for clinical implementation of blood-based biomarkers for Alzheimer’s disease.
1 October, 2024
Alzheimers Dement. 2024 Oct 1. doi: 10.1002/alz.14184. Online ahead of print. PMID: 39351838
Read the article
Dementia in Down syndrome
30 September, 2024
Lakartidningen. 2024 Sep 30;121:23083. PMID: 39354735 Free article. Swedish.
Read the article
Cerebrovascular disease is associated with Alzheimer’s plasma biomarker concentrations in adults with Down syndrome.
25 September, 2024
Brain Commun. 2024 Sep 25;6(5):fcae331. doi: 10.1093/braincomms/fcae331. eCollection 2024.
Read the article
A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer’s Disease.
J Prev Alzheimers Dis. 2024;11(5):1228-1240. doi: 10.14283/jpad.2024.126. PMID: 39350368 Free PMC article. Review.
Read the article
Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions.
19 September, 2024
Acta Neuropathol. 2024 Sep 19;148(1):44. doi: 10.1007/s00401-024-02801-2. PMID: 39297933 Free PMC article.
Read the article
Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease.
16 September, 2024
Alzheimers Res Ther. 2024 Sep 16;16(1):204. doi: 10.1186/s13195-024-01571-z. PMID: 39285454 Free PMC article.
Read the article
Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease.
14 September, 2024
Nat Commun. 2024 Sep 14;15(1):8061. doi: 10.1038/s41467-024-52299-1. PMID: 39277604 Free PMC article.
Read the article
Associations between misfolded alpha-synuclein aggregates and Alzheimer’s disease pathology in vivo.
11 September, 2024
Alzheimers Dement. 2024 Sep 11. doi: 10.1002/alz.14225. Online ahead of print. PMID: 39258841
Read the article
Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies.
26 August, 2024
Nat Neurosci. 2024 Oct;27(10):1880-1891. doi: 10.1038/s41593-024-01737-w. Epub 2024 Aug 26. PMID: 39187705 Free PMC article.
Read the article
The Alzheimer’s Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study.
22 August, 2024
medRxiv . 2024 Aug 22:2024.08.22.24312244. doi: 10.1101/2024.08.22.24312244. PMID: 39228740 Free PMC article. Preprint.
Read the article
The CentiMarker Project: Standardizing Quantitative Alzheimer’s disease Fluid Biomarkers for Biologic Interpretation
29 July, 2024
medRxiv . 2024 Jul 27:2024.07.25.24311002. doi: 10.1101/2024.07.25.24311002.PMID: 39108526 Free PMC article. Preprint.
Read the article
Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care
28 July, 2024
JAMA. 2024 Jul 28:e2413855. doi: 10.1001/jama.2024.13855. Online ahead of print.PMID: 39068545
Read the article
Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment
JAMA Neurol. 2024 Jul 28:e242619. doi: 10.1001/jamaneurol.2024.2619. Online ahead of print.PMID: 39068669 Free PMC article.
Read the article
MRI Signature of α-Synuclein Pathology in Asymptomatic Stages and a Memory Clinic Population
JAMA Neurol. 2024 Jul 28:e242713. doi: 10.1001/jamaneurol.2024.2713. Online ahead of print.PMID: 39068668
Read the article
Harmonizing tau positron emission tomography in Alzheimer’s disease: The CenTauR scale and the joint propagation model
23 July, 2024
Alzheimers Dement. 2024 Jul 23. doi: 10.1002/alz.13908. Online ahead of print.PMID: 39041435
Read the article
A clinical perspective on the revised criteria for diagnosis and staging of Alzheimer’s disease
20 July, 2024
Nat Aging. 2024 Aug;4(8):1029-1031. doi: 10.1038/s43587-024-00675-3.PMID: 39009837. No abstract available.
Read the article
Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study
10 July, 2024
Alzheimers Dement. 2024 Jul 10. doi: 10.1002/alz.14076. Online ahead of print.PMID: 38982845
Read the article
Divergent functional connectivity changes associated with white matter hyperintensities
Neuroimage. 2024 Aug 1;296:120672. doi: 10.1016/j.neuroimage.2024.120672. Epub 2024 Jun 6.PMID: 38851551 Free article.
Read the article
Continuous β-Amyloid CSF/PET Imbalance Model to Capture Alzheimer Disease Heterogeneity
9 July, 2024
Neurology. 2024 Jul 9;103(1):e209419. doi: 10.1212/WNL.0000000000209419. Epub 2024 Jun 11.PMID: 38862136 Free PMC article.
Read the article
Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s disease
6 July, 2024
Alzheimers Res Ther. 2024 Jul 6;16(1):154. doi: 10.1186/s13195-024-01521-9.PMID: 38971815 Free PMC article.
Read the article
A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings
5 July, 2024
Brain. 2024 Jul 5;147(7):2400-2413. doi: 10.1093/brain/awae118.PMID: 38654513 Free PMC article.
Read the article
A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests
medRxiv . 2024 Jul 5:2024.07.02.24309629. doi: 10.1101/2024.07.02.24309629.PMID: 39006421 Free PMC article.
Read the article
Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns
Alzheimers Res Ther. 2024 Jul 5;16(1):153. doi: 10.1186/s13195-024-01517-5.PMID: 38970077 Free PMC article.
Read the article
Acceptable performance of blood biomarker tests of amyloid pathology – recommendations from the Global CEO Initiative on Alzheimer’s Disease
1 July, 2024
Nat Rev Neurol. 2024 Jul;20(7):426-439. doi: 10.1038/s41582-024-00977-5. Epub 2024 Jun 12.PMID: 38866966 Review.
Read the article
Revised criteria for the diagnosis and staging of Alzheimer’s disease
28 June, 2024
Nat Med. 2024 Jun 28. doi: 10.1038/s41591-024-02988-7. Online ahead of print.PMID: 38942991 No abstract available.
Read the article
Revised criteria for diagnosis and staging of Alzheimer’s disease: Alzheimer’s Association Workgroup
27 June, 2024
Alzheimers Dement. 2024 Jun 27. doi: 10.1002/alz.13859. Online ahead of print.PMID: 38934362
Read the article
Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals
26 June, 2024
Alzheimers Res Ther. 2024 Jun 26;16(1):135. doi: 10.1186/s13195-024-01497-6.PMID: 38926747 Free PMC article.
Read the article
Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers
22 June, 2024
Alzheimers Res Ther. 2024 Jun 22;16(1):132. doi: 10.1186/s13195-024-01503-x.PMID: 38909218 Free PMC article.
Read the article
In vivo detection of Alzheimer’s and Lewy body disease concurrence: Clinical implications and future perspectives
21 June, 2024
Alzheimers Dement. 2024 Jun 21. doi: 10.1002/alz.14039. Online ahead of print.PMID: 38955137 Review.
Read the article
Structural and functional connectivity associations with anterior cingulate sulcal variability
20 June, 2024
Brain Struct Funct. 2024 Jun 20. doi: 10.1007/s00429-024-02812-5. Online ahead of print.PMID: 38900167
Read the article
Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study
18 June, 2024
Ann Neurol. 2024 Jun 18. doi: 10.1002/ana.27008. Online ahead of print.PMID: 38888212
Read the article
MRI-Derived AD Signature of Cortical Thinning and Plasma P-Tau217 for Predicting Alzheimer Dementia Among Community-Dwelling Older Adults
15 June, 2024
Neurol Clin Pract. 2024 Jun;14(3):e200291. doi: 10.1212/CPJ.0000000000200291. Epub 2024 Apr 15.PMID: 38720951
Read the article
Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology
Nat Commun. 2024 Jun 15;15(1):5133. doi: 10.1038/s41467-024-49402-x.PMID: 38879548 Free PMC article.
Read the article
Prediction of future cognitive decline among cognitively unimpaired individuals using measures of soluble phosphorylated tau or tau tangle pathology
13 June, 2024
medRxiv . 2024 Jun 13:2024.06.12.24308824. doi: 10.1101/2024.06.12.24308824.PMID: 38947004 Free PMC article. Preprint.
Read the article
Remote and unsupervised digital memory assessments can reliably detect cognitive impairment in Alzheimer’s disease
12 June, 2024
Alzheimers Dement. 2024 Jun 12. doi: 10.1002/alz.13919. Online ahead of print.PMID: 38867417
Read the article
Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment
10 June, 2024
JAMA Neurol. 2024 Jun 10:e241612. doi: 10.1001/jamaneurol.2024.1612. Online ahead of print.PMID: 38857029 Free PMC article.
Read the article
Identification of distinct and shared biomarker panels in different manifestations of cerebral small vessel disease through proteomic profiling
medRxiv . 2024 Jun 10:2024.06.10.24308599. doi: 10.1101/2024.06.10.24308599.PMID: 38947084 Free PMC article. Preprint.
Read the article
A machine learning-based prediction of tau load and distribution in Alzheimer’s disease using plasma, MRI and clinical variables
31 May, 2024
medRxiv . 2024 May 31:2024.05.31.24308264. doi: 10.1101/2024.05.31.24308264.PMID: 38853877 Free PMC article. Preprint.
Read the article
Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly
23 May, 2024
Alzheimers Res Ther. 2024 May 23;16(1):115. doi: 10.1186/s13195-024-01469-w.PMID: 38778353 Free PMC article.
Read the article
Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer’s disease
21 May, 2024
bioRxiv . 2024 May 21:2024.05.21.594976. doi: 10.1101/2024.05.21.594976.PMID: 38826333 Free PMC article. Preprint.
Read the article
Disease staging of Alzheimer’s disease using a CSF-based biomarker model
12 May, 2024
Nat Aging. 2024 May;4(5):694-708. doi: 10.1038/s43587-024-00599-y. Epub 2024 Mar 21.PMID: 38514824 Free PMC article.
Read the article
Plasma p-tau217 in Alzheimer’s disease: Lumipulse and ALZpath SIMOA head-to-head comparison
3 May, 2024
medRxiv . 2024 May 3:2024.05.02.24306780. doi: 10.1101/2024.05.02.24306780.PMID: 38746261 Free PMC article. Preprint.
Read the article
Fixel-Based Analysis Reveals Tau-Related White Matter Changes in Early Stages of Alzheimer’s Disease
1 May, 2024
J Neurosci. 2024 May 1;44(18):e0538232024. doi: 10.1523/JNEUROSCI.0538-23.2024.PMID: 38565289 Free PMC article.
Read the article
Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases
Nat Commun. 2024 May 1;15(1):3676. doi: 10.1038/s41467-024-47971-5.PMID: 38693142 Free PMC article.
Read the article
Biomarker-based staging of Alzheimer disease: rationale and clinical applications
20 April, 2024
Nat Rev Neurol. 2024 Apr;20(4):232-244. doi: 10.1038/s41582-024-00942-2. Epub 2024 Mar 1.PMID: 38429551 Review.
Read the article
Associations between structural brain changes and blood neurofilament light chain protein in treatment-resistant schizophrenia
8 April, 2024
medRxiv . 2024 Apr 8:2024.04.07.24305362. doi: 10.1101/2024.04.07.24305362.PMID: 38645076 Free PMC article. Preprint.
Read the article
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
28 March, 2024
Res Sq . 2024 Mar 28:rs.3.rs-4103685. doi: 10.21203/rs.3.rs-4103685/v1.PMID: 38585969 Free PMC article. Preprint.
Read the article
Altered empathy processing in frontotemporal dementia A task-based fMRI study
26 March, 2024
bioRxiv . 2024 Mar 26:2024.03.21.586051. doi: 10.1101/2024.03.21.586051.PMID: 38585830 Free PMC article. Preprint.
Read the article
Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms
19 March, 2024
Alzheimers Res Ther. 2024 Mar 19;16(1):61. doi: 10.1186/s13195-024-01428-5.PMID: 38504336 Free PMC article.
Read the article
Is GBA1 T369M not a risk factor for Parkinson’s disease in the Swedish population?
16 March, 2024
medRxiv . 2024 Mar 16:2024.03.15.24304347. doi: 10.1101/2024.03.15.24304347.PMID: 38559109 Free PMC article. Preprint.
Read the article
A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings
14 March, 2024
Nat Commun. 2024 Mar 14;15(1):2311. doi: 10.1038/s41467-024-46603-2.PMID: 38486040 Free PMC article.
Read the article
Prognostic and Predictive Factors in Early Alzheimer’s Disease: A Systematic Review.
16 February, 2024
J Alzheimers Dis Rep. 2024 Feb 16;8(1):203-240. doi: 10.3233/ADR-230045. eCollection 2024.PMID: 38405341 Free PMC article.
Read the article
A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases.
14 September, 2023
Nat Aging. 2023 Aug 31. doi: 10.1038/s43587-023-00471-5.
Read the article
Cognitive effects of Lewy body pathology in clinically unimpaired individuals.
Nat Med. 2023 Aug;29(8):1971-1978. doi: 10.1038/s41591-023-02450-0.
Read the article
Clinical effects of Lewy body pathology in cognitively impaired individuals.
Nat Med. 2023 Aug;29(8):1964-1970. doi: 10.1038/s41591-023-02449-7.
Read the article
CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease.
Nat Med. 2023 Aug;29(8):1954-1963. doi: 10.1038/s41591-023-02443-z.
Read the article
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring.
Nat Med. 2022 Dec;28(12):2555-2562. doi: 10.1038/s41591-022-02074-w.
Read the article
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline.
Nat Med. 2022 Nov;28(11):2381-2387. doi: 10.1038/s41591-022-02049-x.
Read the article