6/🧵Taken together, we present an accurate two-step approach for predicting LBP in the brain using a smell test followed by CSF SAA testing in smell-test positive individuals. This could minimize costs, reduce patient burden, and improve the known underdiagnosis of DLB and PD.

A huge thanks to all authors and collaborators who made this work possible! @OskarHansson9 @LECollij @_JakeVogel_ @SebastianPalmqv @FBarkhof @RikOssenkoppele and all not on X.

7⃣This suggests that region-specific atrophy functions as one pathway of tau-induced cognitive subdomain impairments. Yet, large portions of variance remains unexplained, highlighting the need for investigating other mechanistic links.🔬

8⃣A huge thank you to all authors as well as the #ADNI study participants who made this work possible. Your contributions are vital for advancing our understanding of the disease and contribute to #ENDALZ.

In conclusion, p-Tau217ALZpath exhibited similar performance to p-Tau181Lilly, but its correlations with AD pathology measures were significantly lower than p-Tau217Lilly. Future studies are needed to replicate these findings in larger cohorts.

Big thanks to all the co-authors for their invaluable contributions: @gesalbla, Thomas Beach, Geidy Serrano, Alireza Atri, Eric Reiman, Andreas Jeromin, @OskarHansson9, and Shorena Janelidze.

7⃣These findings support implementation of especially plasma p-tau217, and potentially also GFAP, in prognostic workup of AD in people with DS in both clinical practice and drug trials.

A huge thanks to the @abc_ds_ team, all co-authors, and the participants of the study.

6/🧵Concluding, plasma assays specific for LMW p-tau are preferable in the diagnostic workup of AD, with fewer false positive findings, especially in diverse population-based communities where peripheral neuropathy may produce high p-tau levels when using non-LMW specific assays.

A big thank you to all our collaborators from Bologna, Umeå, and Gothenburg and a special thanks to all co-authors @NicholasAshton @A_OrdunaDolado @DivyaBali06 @NiklasMattsson4 @OskarHansson9
and all not on X!

6/🧵Our findings suggest that regional vulnerability to Aβ, not reduced inter-hemispheric connectivity, drives asymmetric tau accumulation in AD. This strengthens the link between Aβ and tau and supports the evidence of early anti-Aβ interventions to help limit tau buildup.

Big thanks to all co-authors and collaborators!
@RikOssenkoppele @ErikRubenSmith @LECollij @aitchbi @jorittmo @karlssonlinda1 @DaniellevWe @_JakeVogel_ @EStomrud @SebastianPalmqv @NiklasMattsson4 @NicolaSpotorno @OskarHansson9 + those not on X