The tau biomarker cascade is condensed in Down syndrome compared to sporadic Alzheimer’s disease

2025

Zammit MD, Bruzzone H, Cody KA, Morse J, Wilson R, Bettcher BT, McLachlan MJ, McVea AK, DiFilippo AH, Carey FJ, Janelidze S, Hansson O, Price JC, Laymon CM, Minhas DS, Luo W, Rosas HD, Lai F, Lee JH, Lao PJ, Ances BM, Krinsky-McHale SJ, Hom CL, Hartley SL, Zaman SH, Johnson SC, Cohen AD, Head E, Mapstone ME, Handen BL, Christian BT, Tudorascu DL, Langhough RE, Betthauser TJ; Alzheimer Biomarker Consortium–Down Syndrome.

Brain. 2025 Nov 15:awaf428. doi: 10.1093/brain/awaf428. Online ahead of print. PMID: 41240365