It is today possible to detect accumulation of Tau in the brain with novel specific radio ligands that are visualized using PET imaging technology. Due to the novelty the number of published studies is limited but it has been shown that Tau PET imaging can detect cerebral Tau pathology.
In collaboration with AVID/Lilly (USA) we have access to the precursor to produce the radio ligand 18F-AV1451 (previously named T807) that in preliminary studies have shown to visualize Tau-pathology in the brain with PET imaging. The figures above show a subject with Alzheimer’s disease with an increased parieto-temporal uptake of the ligand and a cognitively healthy elderly (coronal and sagittal sections).
We will in the future have access to the precursor of another promising PET radio ligand (18F-THK-5351) via Tohoku University (Japan).
The two substances have been tested in Phase I studies and is safe for the patients and no negative events has been reported. The first 18F-AV1451 PET-scans are currently being performed at SUS.